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- Title
You have free access to this contentTargeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
- Authors
Di Napoli, Arianna; Jain, Preti; Duranti, Enrico; Margolskee, Elizabeth; Arancio, Walter; Facchetti, Fabio; Alobeid, Bachir; Santanelli di Pompeo, Fabio; Mansukhani, Mahesh; Bhagat, Govind
- Abstract
The article focuses on next generation sequencing of breast implant associated anaplastic large cell lymphoma (BI-ALCL) which reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A. It mentions BI-ALCL is characterized by the presence of CD30 with atypical lymphocytes frequently confined to the peri-implant seroma fluid. It also mentions identification of biomarkers that enable disease prognostication and optimal treatment.
- Subjects
BREAST implants; ANAPLASTIC lymphoma kinase; LYMPHOCYTES; BIOMARKERS; GENETIC mutation
- Publication
British Journal of Haematology, 2018, Vol 180, Issue 5, p741
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.14431