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- Title
Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample.
- Authors
Ingelsson, Erik; Larson, Martin G; Yin, Xiaoyan; Wang, Thomas J; Meigs, James B; Lipinska, Izabella; Benjamin, Emelia J; Keaney, John F Jr; Vasan, Ramachandran S
- Abstract
<bold>Context: </bold>The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown.<bold>Objective: </bold>The objective of the study was to study the cross-sectional relations of these adipokines to cardiometabolic risk factors in a community-based sample.<bold>Design, Setting, and Participants: </bold>We measured circulating ghrelin, leptin, and sOB-R in 362 participants (mean age 45 yr; 54% women) of the Framingham Third Generation Cohort.<bold>Main Outcome Measures: </bold>Body mass index, waist circumference (WC), blood pressure, lipid measures, fasting glucose, smoking, and metabolic syndrome (MetS) were measured.<bold>Results: </bold>Ghrelin and leptin concentrations were significantly higher in women (P < 0.0001). In multivariable models, ghrelin was inversely associated with age and systolic blood pressure, and leptin was positively related to body mass index and WC. sOB-R was positively associated with age, total cholesterol, and fasting glucose and inversely with WC and high-density lipoprotein cholesterol. Ghrelin and sOB-R concentrations were significantly lower with number of MetS components (P for trend = 0.022 and < 0.0001, respectively), whereas leptin concentrations were higher (P for trend = 0.0001). Relating all adipokines to MetS conjointly, higher ghrelin and leptin concentrations were associated with decreased and increased odds of MetS (odds ratio 0.55, P < 0.0001; odds ratio 4.44, P = 0.0002, per 1 sd increase of respective log adipokine).<bold>Conclusions: </bold>In our community-based sample, we observed a sexual dimorphism in circulating ghrelin and leptin concentrations. Ghrelin, leptin, and sOB-R were associated with number of MetS components cross-sectionally, consistent with the hypothesis that these adipokines may have a central role in cardiometabolic risk.
- Subjects
CARDIOVASCULAR diseases; CELL receptors; COMPARATIVE studies; ENERGY metabolism; HUMAN reproduction; RESEARCH methodology; MEDICAL cooperation; MULTIVARIATE analysis; RESEARCH; RESEARCH funding; LEPTIN; EVALUATION research; GHRELIN; METABOLIC syndrome; BODY mass index; BLOOD
- Publication
Journal of Clinical Endocrinology & Metabolism, 2008, Vol 93, Issue 8, p3149
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2008-0207