We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The classification of diabetes by clinical and C-peptide criteria. A prospective population-based study.
- Authors
Service FJ; Rizza RA; Zimmerman BR; Dyck PJ; O'Brien PC; Melton LJ III; Service, F J; Rizza, R A; Zimmerman, B R; Dyck, P J; O'Brien, P C; Melton, L J 3rd
- Abstract
<bold>Objective: </bold>To evaluate both the concordance in the classification of diabetes by clinical and C-peptide criteria and, prospectively, the consistency of the classification by C-peptide.<bold>Research Design and Methods: </bold>Individuals with diabetes who were enlisted in the prospective epidemiological study of diabetic neuropathy (Rochester Diabetic Neuropathy Study [RDNS]) were classified clinically by National Diabetes Data Group (NDDG) criteria to IDDM and NIDDM at entry to the study. In addition, C-peptide response to 1 mg glucagon was measured at entry for the classification to IDDM (basal C-peptide, < 0.17 pmol/ml; increment above basal, < 0.07 pmol/ml) and NIDDM (all other responses) and for concordance with the clinical classification made. The consistency of the C-peptide response was assessed every 2 years for up to 8 years.<bold>Results: </bold>Among 346 individuals with diabetes, 84 were classified as IDDM and 262 as NIDDM by clinical algorithm. COncordance with the C-peptide response occurred in 89% of the patients and remained consistent during 8 years of follow-up. Among the 37 patients with discordant clinical and C-peptide classification, those considered clinically to have NIDDM had a consistent IDDM C-peptide response during follow-up, and most of those considered to have IDDM clinically eventually showed an IDDM C-peptide response during follow-up.<bold>Conclusions: </bold>Clinical criteria for the classification of diabetes are highly correlated with the assessment of insulin secretory reserve. A small number of individuals considered to have NIDDM clinically or by C-peptide have or develop an IDDM peptide response.
- Publication
Diabetes Care, 1997, Vol 20, Issue 2, p198
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.20.2.198