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- Title
Programmed Death Ligand-1 (PD-L1) Expression in Either Tumor Cells or Tumor-Infiltrating Immune Cells Correlates With Solid and High-Grade Lung Adenocarcinomas.
- Authors
Driver, Brandon R.; Miller, Ross A.; Miller, Tara; Deavers, Michael; Gorman, Blythe; Mody, Dina; Ge, Yimin; Barrios, Roberto; Bernicker, Eric; Kim, Min; Cagle, Philip T.
- Abstract
Context.--Programmed death ligand-1 (PD-L1) expression in non--small cell lung carcinoma (NSCLC) is heterogeneous and known to be underestimated on small biopsies. Correlation of PD-L1 expression with clinicopathologic features may provide additional useful information. To our knowledge, the clinicopathologic features of NSCLC have not been reported for subsets defined by PD-L1 expression in either tumor cells or tumor-infiltrating immune cells. Objective.--To investigate the clinicopathologic characteristics of NSCLC subsets defined by PD-L1 expression in either tumor cells or tumor-infiltrating immune cells. Design.--PD-L1 immunohistochemistry with the SP142 clone was performed on whole-tissue sections and given semiquantitative scores (0/1/2/3) according to percent of PD-L1þ tumor cells (TCs) and percent tumor area with PDL1þ tumor-infiltrating immune cells (ICs). Results.--Adenocarcinoma cases that were scored either TC 1/2/3 or IC 1/2/3 included most (22 of 34; 65%) high--histologic grade cases and most (25 of 36; 69%) solid subtype cases. Compared with the adenocarcinoma TC 0 and IC 0 subset, the TC 1/2/3 or IC 1/2/3 subset correlated with higher histologic grade (P = .005, χ² test for trend) and solid subtype (P < .001, Fisher exact test). Compared with the adenocarcinoma TC 0/1 or IC 0/1 subset, the TC 2/3 or IC 2/3 subset correlated with higher histologic grade (P=.002, χ² test for trend), solid subtype (P < .001, Fisher exact test), and higher smoking pack-years (P = .01, Mann-Whitney test). Conclusions.--Lung adenocarcinoma subsets defined by PD-L1 expression in either tumor cells or tumor-infiltrating immune cells correlated with high histologic grade, solid subtype, and high smoking pack-years.
- Subjects
ADENOCARCINOMA; ANTIGENS; CHI-squared test; FISHER exact test; IMMUNOHISTOCHEMISTRY; LONGITUDINAL method; LUNG cancer; SQUAMOUS cell carcinoma; TUMOR classification; DATA analysis software; MANN Whitney U Test
- Publication
Archives of Pathology & Laboratory Medicine, 2017, Vol 141, Issue 11, p1529
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/arpa.2017-0028-OA