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- Title
Neuromuscular and vascular hamartoma of the small intestine in an F344 rat.
- Authors
Takanori Yamada; Takeshi Toyoda; Tetsuya Ide; Kohei Matsushita; Tomomi Morikawa; Kumiko Ogawa
- Abstract
An intestinal mass was found in the border area of the jejunum and ileum of a 110-week-old male F344 rat. Histopathologically, the mass protruded into the lumen and was covered with intestinal epithelium, exhibiting a normal architecture. The lesion was located in the submucosa and consisted of loose connective tissue, smooth muscle, scattered ganglion cells, and blood vessels of various sizes. Although these components showed an irregular and disordered structure, no cellular atypia, increased proliferation activity, or invasive growth to adjacent tissues were detected. Immunohistochemical analyses revealed that smooth muscle, ganglion, and endothelial cells were positive for a-smooth muscle actin and vimentin, S-100, and CD34 and von Willebrand factor, respectively, indicating maturation of these cells. Thus, the mass was diagnosed as a neuromuscular and vascular hamartoma of the small intestine. To the best of our knowledge, this is the first report of this type of lesion in rodents.
- Subjects
HAMARTOMA; CONNECTIVE tissues; VON Willebrand factor; SMOOTH muscle; RATS; SMALL intestine
- Publication
Journal of Toxicologic Pathology, 2021, Vol 34, Issue 1, p113
- ISSN
0914-9198
- Publication type
Article
- DOI
10.1293/tox.2020-0059