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- Title
Biological Therapies for Pediatric Atopic Dermatitis - A Review.
- Authors
Milano, Giulia; Forestieri, Stefano; Tedeschi, Micol; Licari, Amelia; Brazzelli, Valeria; Marseglia, Gian Luigi
- Abstract
Atopic dermatitis (AD) is the most frequent chronic-recurrent inflammatory skin disease in the pediatric age. It has a complex and multifactorial pathogenesis: the two key actors are impaired skin barrier function and immune system dysregulation, which represent the main targets of AD therapy. Monoclonal antibodies have revolutionized the management of moderate-to-severe AD, by selective inhibition of key cytokines in the pathogenetic process. For this reason, there is great interest in exploring AD pathogenetic mechanisms to develop new therapeutic strategies. This review aims to summarize the most recent scientific evidence on available and future biological therapies for the treatment of pediatric AD, emphasizing the molecular mechanisms underlying their action.
- Subjects
ATOPIC dermatitis treatment; CYTOKINES; BIOLOGICAL products; SKIN; PEDIATRICS; IMMUNE system; MONOCLONAL antibodies; BIOTHERAPY; ATOPIC dermatitis
- Publication
Current Pediatric Reviews, 2024, Vol 20, Issue 3, p240
- ISSN
1573-3963
- Publication type
Article
- DOI
10.2174/1573396320666230912103136