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- Title
An Erythropoietin Gene Polymorphism in the Hypoxia-Responsive Element at Position 3434 Is Possibly Associated with Hypertension.
- Authors
Schulz, E.G.; Neumann, C.L.; Menne, J.; Schettler, V.; Mackenbrock, C.; Popov, A.F.; Hagenah, G.C.; Hinz, J.; Bargfeldt, M.; Gasser, T.; Haller, H.; Hermann, M.
- Abstract
Background/Aims: Several polymorphisms of vasoactive hormones have been implicated in hypertension. Erythropoietin (EPO) interacts with vasoactive substances, such as angiotensin II. Previously detected single nucleotide polymorphisms in the hypoxia-responsive element of EPO might be associated with hypertension and hypertensive end organ damages. Methods: 400 hypertensive patients and 200 age- and gender-matched normotensive controls were genotyped for an EPO polymorphism [cytosine (C)/thymine (T) single nucleotide polymorphism] at position 3434. Patients were grouped according to their genotype into the CC group (CC genotype) and the CT/TT group (CT and TT genotype). BP was measured by ambulatory BP monitoring. Results: The CC genotype was present in 87% of hypertensive patients and in 78.5% of controls (p = 0.007). In addition, patients with the CC genotype had higher BP levels compared with CT/TT genotypes (BPsys 143.7 ± 20.4 vs. 136.1 ± 13.5 mm Hg, p = 0.01, and BPdias 85.8 ± 11.6 vs. 82.4 ± 8.9, p = 0.043) despite a nearly identical number of antihypertensive drugs (2.3 ± 1.5 vs. 2.3 ± 1.6; p = 0.257). 100% of the small number of patients with end-stage renal disease (n = 15) had the CC genotype. Conclusion: The CC genotype of the EPO gene at position 3434 is more frequently found in patients with hypertension and is associated with higher BP levels. Copyright © 2011 S. Karger AG, Basel
- Subjects
GENETIC polymorphism research; HYPERTENSION; ERYTHROPOIETIN; HYPOXEMIA; BLOOD pressure
- Publication
Kidney & Blood Pressure Research, 2012, Vol 35, Issue 2, p71
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000330245