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- Title
Randomized, double-blind, placebo-controlled trial of Ficus carica paste for the management of functional constipation.
- Authors
Baek, Hyang-Im; Ha, Ki-Chan; Kim, Hye-Mi; Choi, Eun-Kyung; Park, Eun-Ock; Park, Byung-Hyun; Yang, Hye Jeong; Kim, Min Jung; Kang, Hee Joo; Chae, Soo-Wan
- Abstract
<bold>Background and Objectives: </bold>Constipation affects up to 20% of the world's population. The aim of this study was to investigate whether supplementation with Ficus carica paste could be used to treat constipation in Korean subjects with functional constipation.<bold>Methods and Study Design: </bold>We conducted a randomized, double-blind, placebo-controlled trial. Subjects with functional constipation were orally supplemented with either F. carica paste (n=40) or placebo (n=40) for 8 weeks. We measured the efficacy and safety of F. carica paste. Primary outcomes (colon transit time) and secondary outcomes (questionnaire related to defecation) were compared before and after the 8-week intervention period.<bold>Results: </bold>F. carica paste supplementation was associated with a significant reduction in colon transit time and a significant improvement in stool type and abdominal discomfort compared with the placebo. Blood parameters and clinical findings for organ toxicity remained within normal ranges.<bold>Conclusion: </bold>These results suggest that F. carica paste may have beneficial effects in subjects suffering from constipation.
- Subjects
SOUTH Korea; COMPARATIVE studies; CONSTIPATION; DIET; DIETARY supplements; DIETARY fiber; FIG; FLAVONOIDS; FRUIT; GASTROINTESTINAL motility; HERBAL medicine; RESEARCH methodology; MEDICAL cooperation; PLACEBOS; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment
- Publication
Asia Pacific Journal of Clinical Nutrition, 2016, Vol 25, Issue 3, p487
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.092015.06