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- Title
Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions.
- Authors
Dine, Tharwat Mohy El; Evans, David; Rouden, Jacques; Blanchet, Jérôme
- Abstract
A highly efficient and mild transamidation of amides with amines co-catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral α-amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron-derived Lewis acidity rather than an improved Brønsted acidity of acetic acid.
- Subjects
CHEMICAL synthesis; FORMAMIDE; BORINIC acids; CATALYSIS; AMIDATION
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 17, p5894
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201600234