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- Title
Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY.
- Authors
Virts, Natalia A.; Karogodina, Tatyana Yu.; Panfilov, Mikhail A.; Vorob'ev, Alexey Yu.; Moskalensky, Alexander E.
- Abstract
Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.
- Subjects
STAINS &; staining (Microscopy); LIGHT sources; POLYMER films; BIOMEDICAL materials; NITRIC oxide; ELECTROCHEMICAL sensors; SILICONES
- Publication
Journal of Functional Biomaterials, 2024, Vol 15, Issue 4, p92
- ISSN
2079-4983
- Publication type
Article
- DOI
10.3390/jfb15040092