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- Title
Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized <sup>13</sup>C,<sup>15</sup>N-Urea.
- Authors
Bertelsen, Lotte B.; Nielsen, Per M.; Qi, Haiyun; Nørlinger, Thomas S.; Zhang, Xiaolu; Stødkilde‐Jørgensen, Hans; Laustsen, Christoffer
- Abstract
Purpose In the current study, we investigated hyperpolarized urea as a possible imaging biomarker of the renal function by means of the intrarenal osmolality gradient. Methods Hyperpolarized three-dimensional balanced steady state 13C MRI experiments alongside kidney function parameters and quantitative polymerase chain reaction measurements was performed on two groups of rats, a streptozotocin type 1 diabetic group and a healthy control group. Results A significant decline in intrarenal steepness of the urea gradient was found after 4 weeks of untreated insulinopenic diabetes in agreement with an increased urea transport transcription. Conclusion MRI and hyperpolarized [13C,15N]urea can monitor the changes in the corticomedullary urea concentration gradients in diabetic and healthy control rats. Magn Reson Med 77:1650-1655, 2017. © 2016 International Society for Magnetic Resonance in Medicine
- Publication
Magnetic Resonance in Medicine, 2017, Vol 77, Issue 4, p1650
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.26256