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- Title
Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose.
- Authors
D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Mayol, Luciano; Piccialli, Gennaro
- Abstract
The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5′-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached to the 4-N-position of AICAR. Cyclization of the diphosphate derivative by pyrophosphate bond formation allowed for the formation of a novel AICAR-based cyclic ADP-ribose (cADPR) mimic.
- Subjects
SOLID-phase synthesis; PYROPHOSPHATES; RIBOSE phosphates; MOIETIES (Chemistry); RING formation (Chemistry)
- Publication
Molecules, 2011, Vol 16, Issue 9, p8110
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules16098110