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- Title
Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats.
- Authors
Nan Li; Lu-Ping Qin; Ting Han; Yan-Bin Wu; Qiao-Yan Zhang; Hong Zhang
- Abstract
The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-α and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.
- Subjects
BONES; MORINDA; ALCOHOL; TIBIA; BONE density; PHOSPHORUS; CALCIUM; CORTICOSTERONE; LABORATORY rats
- Publication
Molecules, 2009, Vol 14, Issue 6, p2049
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14062049