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- Title
Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines.
- Authors
Drag, Marcin; Surowiak, Pawel; Drag-Zalesinska, Malgorzata; Dietel, Manfred; Lage, Hermann; Oleksyszyn, Józef
- Abstract
Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drugsensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer.
- Subjects
BETULIN; CELL lines; BIRCH bark extract; ANTINEOPLASTIC antibiotics; ANTINEOPLASTIC agents; CANCER treatment; MITOXANTRONE hydrochloride; PANCREATIC cancer; STOMACH cancer; PHYSIOLOGY; THERAPEUTICS
- Publication
Molecules, 2009, Vol 14, Issue 4, p1639
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14041639