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- Title
Factors affecting the distribution of folate forms in the serum of elderly German adults.
- Authors
Kirsch, Susanne; Herrmann, Wolfgang; Eckert, Rudolf; Geisel, Jürgen; Obeid, Rima
- Abstract
Purpose: We investigated the roles of age, vitamin B markers, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism as determinants of folate forms in serum. Methods: We measured the serum concentrations of (6 S)-5-CH-Hfolate, (6 S)-Hfolate, (6 S)-5-HCO-Hfolate, (6 R)-5,10-CH-Hfolate, and folic acid in 146 non-supplemented older participants (median age 74 years). The concentrations of total vitamin B, holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine (tHcy) were also measured. Results: Elevated metabolites (MMA > 271 nmol/L and tHcy > 12.0 μmol/L) were found in 24.0 and 63.0 % of the participants, respectively. We found a significant age-dependent decrease (participants with a median age of 87 years compared with participants with a median age of 60 years) in the sum of serum folate levels, the (6 S)-5-CH-Hfolate concentration, and the (6 S)-5-CH-Hfolate proportion. In addition, participants with elevated metabolite levels were older, had lower concentrations of the sum of folates and (6 S)-5-CH-Hfolate, and had higher concentrations of (6 S)-5-CHO-Hfolate and creatinine but had a comparable holoTC/total vitamin B ratio. No association was found between the MTHFR C677T genotype and serum folate forms. Conclusion: Low serum (6 S)-5-CH-Hfolate concentrations and the proportion of (6 S)-5-CH-Hfolate (percentage of the sum of folate forms) are related to older age and elevated MMA and tHcy levels.
- Subjects
GERMANY; FOLIC acid metabolism; AGE distribution; ANALYSIS of variance; CHI-squared test; FOLIC acid; GENETIC polymorphisms; STATISTICS; T-test (Statistics); U-statistics; VITAMIN B12; DATA analysis; DATA analysis software; DESCRIPTIVE statistics
- Publication
European Journal of Nutrition, 2013, Vol 52, Issue 2, p497
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-012-0351-3