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- Title
Fibroblast Growth Factor Receptor 1 as a Target for the Therapy of Renal Cell Carcinoma.
- Authors
Tsimafeyeu, Ilya; Bratslavsky, Gennady
- Abstract
Dysregulation of fibroblast growth factor (FGF) signaling in renal cell carcinoma is now well understood, and it is becoming increasingly likely that certain tumors become dependent on an activation of this pathway for their growth and survival. Dissecting the FGF/FGF receptor (FGFR) pathway offers the hope of developing new therapeutic approaches that selectively target the FGF/FGFR axis in patients whose tumors are known to harbor FGF/FGFR dysregulation. In this review, we summarize the existing data on the role of FGFR1 in the pathogenesis of renal cell carcinoma and discuss methodological issues for drug investigation in this setting. © 2015 S. Karger AG, Basel
- Subjects
FIBROBLASTS; CANCER treatment; CELL receptors; DATABASES; META-analysis; RENAL cell carcinoma; SYSTEMATIC reviews; VASCULAR endothelial growth factors; PHYSIOLOGY; CELL physiology
- Publication
Oncology, 2015, Vol 88, Issue 6, p321
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000370118