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- Title
Clinical Significance of Insulin-Like Growth Factor Type 1 Receptor and Epidermal Growth Factor Receptor in Patients with Advanced Gastric Cancer.
- Authors
Matsubara, Junichi; Yamada, Yasuhide; Nakajima, Takako E.; Kato, Ken; Hamaguchi, Tetsuya; Shirao, Kuniaki; Shimada, Yasuhiro; Shimoda, Tadakazu
- Abstract
Objective: To better understand the clinical implications of insulin-like growth factor type 1 receptor (IGF-1R), epidermal growth factor receptor (EGFR) and HER2 expressions in gastric cancer (GC). Methods: The study group comprised 86 patients who received first-line chemotherapy for advanced GC at the National Cancer Center Hospital. Using laser-captured microdissection and a real-time RT-PCR assay, we quantitatively evaluated mRNA levels of IGF-1R, EGFR and HER2 in paraffin-embedded cancer specimens of surgically removed primary tumors. Results: In univariate analysis of the study group as a whole, patients with low expression of both IGF-1R and EGFR (n = 13) had a significantly longer overall survival than the other patients (n = 51; median, 24.6 vs. 12.8 months; log-rank p = 0.013). Multivariate survival analysis demonstrated that high EGFR expression [hazard ratio, HR: 2.94 (95% confidence interval, CI: 1.40–6.17), p = 0.004] and poor performance status [HR: 1.96 (95% CI: 1.12–3.42), p = 0.018] were significant predictors of poor survival. In patients given first-line S-1 monotherapy (n = 29), low IGF-1R (p = 0.002) and low EGFR (p = 0.035) gene expression correlated with a better response, without a significant prolongation of survival. Conclusion: Our data warrant further investigations on the strategy of co-targeting IGF-1R and EGFR in GC. Copyright © 2008 S. Karger AG, Basel
- Subjects
STOMACH cancer; SOMATOMEDIN; EPIDERMAL growth factor; MICRODISSECTION; CANCER treatment
- Publication
Oncology, 2008, Vol 74, Issue 1/2, p76
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000139127