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- Title
Effects of DQ-2511, a Novel Prokinetic Agent, on Electrical Activities of Smooth Muscle in the Guinea Pig Stomach.
- Authors
Imaeda, Kenro; Hashitani, Hikaru; Xue, Lin; Yamamoto, Yoshimichi; Itoh, Makoto; Suzuki, Hikaru
- Abstract
Electrophysiological experiments were carried out to investigate the prokînetic actions of DQ-2511 on isolated smooth muscle of the guinea pig stomach. DQ-2511 enhanced the myogenic gastric slow waves and cholinergic excitatory junction potential and reduced the frequency of slow waves and the nonadrenergic, noncholinergic, and nonnitrergic inhibitory junction potential, with no significant alteration of the resting membrane potential. The results suggest that the prokînetic actions of DQ-2511 involve excitatory actions directly on smooth muscle and indirectly on cholinergic transmission. Copyright © 1997 S. Karger AG, Basel
- Publication
Pharmacology, 1997, Vol 55, Issue 3, p144
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000139522