We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acute Leukemia after Treatment for Ovarian Cancer.
- Authors
De Gramont, Aimery; Remes, Philippe; Krulik, Marcel; Smadja, Nicole; Drolet, Yvan; Donadio, Daniel; Louvet, Christophe; Brissaud, Philippe; Sirinelli, Agnes; Dray, Claude; Debray, Jacques
- Abstract
Four cases of acute nonlymphocytic leukemia (ANLL) following ovarian cancer are reported. All patients received alkylating agents and had a preleukemic phase. Seventy-nine additional cases of ANLL following therapy found in the literature are also reviewed. All but 2 patients received alkylating or alkylating-related agents alone or in combination. Mean duration of chemotherapy was 31.4 ± 19.4 months. Eighty-eight percent of the patients presented with preleukemia with a mean duration of 10 ± 10 months. Mean interval between cancer and ANLL was 57.3 ± 26 months. Cytogenetic abnormalities were found in 71% among patients who had a karyotype. Long-term alkylating agent therapy seems to have a significant role in the development of ANLL and should be avoided in ovarian cancer. Copyright © 1986 S. Karger AG, Basel
- Publication
Oncology, 1986, Vol 43, Issue 3, p165
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226357