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- Title
SYNTHESIS AND CHARACTERIZATION OF SOME NEW NITRONES DERIVATIVES AND SCREENING THEIR BIOLOGICAL ACTIVITIES.
- Authors
Mohammed, Jihad Haji; Mohammad Salih, Nabaz Abdulmajeed
- Abstract
Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding phenylhydroxylamine in presence of zinc dust as reducing agent in aqueous solution of ammonium chloride (NH4Cl). The prepared phenylhydroxylamine derivatives were reacted with different substituted benzaldehydes to give the target derivatives of nitrone. The structures of the synthesized nitrones were characterized by spectroscopic methods FT-IR, 1HNMR and 13C NMR. Finally, the newly synthesized compounds were screened for their microorganism activities at different concentration, and inhibited growth of Escherichia coli (E. coli) Gram negative, Staphylococcus aureus (S. aureus) Gram positive, and fungi (candida albicans).
- Subjects
NITRONES; STAPHYLOCOCCUS aureus; AMMONIUM chloride; NUCLEAR magnetic resonance; AQUEOUS solutions
- Publication
Science Journal of University of Zakho, 2023, Vol 11, Issue 2, p160
- ISSN
2663-628X
- Publication type
Article
- DOI
10.25271/sjuoz.2023.11.2.1149