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- Title
Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos.
- Authors
Dan-Goor, Mary; Sasson, Shlomo; Davarashvili, Anna; Almagor, Miriam; Dan-Goor, M; Sasson, S; Davarashvili, A; Almagor, M
- Abstract
The expression of glucose transporters 1, 2, 3 and 4 was evaluated in human oocytes and polyploid preimplantation embryos. Only glucose transporter 1 (GLUT-1) isoform was detected in oocytes and in 2–12-cell stage embryos. Glucose uptake was markedly increased in embryos as compared to oocytes (19.7 ± 3.4 pmol/min/embryo and 2.3 ± 0.3 pmol/min/oocyte), and GLUT-1 was inhibited by cytochalasin B. These results suggest that, although GLUT-1 is expressed in human oocytes and throughout preimplantation development, its function in mediating the rise in glucose uptake is triggered following fertilization.
- Publication
Human Reproduction, 1997, Vol 12, Issue 11, p2508
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/12.11.2508