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- Title
High mobility group box- 1 levels may be associated with disease activity of Behcet’s disease.
- Authors
DÖNMEZ GÜLER, Dilara; KELEŞOĞLU DİNÇER, Ayşe Bahar; KARAHAN, Zeynep Ceren; GÜLER, Hasan Selim; YAYLA, Müçteba Enes; SEZER, Serdar; AYDEMİR GÜLÖKSÜZ, Emine Gözde; OKATAN, İlyas Ercan; TORGUTALP, Murat; ŞAHİN EROĞLU, Didem; YÜKSEL, Mehmet Levent; TURGAY, Tahsin Murat; KINIKLI, Gülay; ATEŞ, Aşkın
- Abstract
Background/aim: High mobility group box- 1 (HMGB- 1) is a nuclear protein acting as a proinflammatory molecule. The serum HMGB- 1 levels were found elevated in chronic inflammatory diseases. In this cross-sectional study, serum HMGB- 1 levels in Behcet’s disease (BD) patients and healthy controls (HC) were studied. Also, its association with disease activity scores and clinical findings were evaluated. Materials and methods: Ninety BD patients and 50 age-sex matched HC were included in the study. Disease activity scores were assessed by Behcet Disease Current Activity Form (BDCAF) and Behcet Syndrome Activity Score (BSAS). Serum HMGB- 1 levels were measured using a commercial ELISA kit. A p value of < 0.05 was considered to be statistically significant. Results: Serum HMGB- 1 levels were significantly higher in BD than in HC (43.26 pg/mL and 16.73 pg/mL; p < 0.001, respectively). Serum HMGB- 1 levels were statistically significantly associated with presence of erythema nodosum (EN) and genital ulcers in the last one month prior to recruitment (p = 0.041 and p < 0.001, respectively). BDCAF and BSAS scores were positively correlated with serum HMGB- 1 level ( p = 0.03 and p = 0.02, respectively). Conclusion: HMGB - 1 may play a role in the development of BD. Also, due to its positive correlation with disease activity indices, it can be used as a novel disease activity parameter in BD.
- Subjects
BEHCET'S disease; ERYTHEMA nodosum; NUCLEAR proteins
- Publication
Turkish Journal of Medical Sciences, 2021, Vol 51, Issue 5, p2690
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-2101-116