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- Title
Prognostic Significance of Peripheral T‐Cell Subsets in Laryngeal Squamous Cell Carcinoma.
- Authors
Marchi, Filippo; Missale, Francesco; Incandela, Fabiola; Filauro, Marta; Mazzola, Francesco; Mora, Francesco; Paderno, Alberto; Parrinello, Giampiero; Piazza, Cesare; Peretti, Giorgio
- Abstract
Objectives: The role of the immune system in head and neck squamous cell carcinoma is controversial. The aim of our study was to analyze full blood counts and distribution of T cell subsets in patients affected by laryngeal squamous cell cancer (LSCC) and their association with clinical variables and survival. Study design: Retrospective study. Methods: We analyzed the levels of platelets, lymphocytes, and neutrophils, as well as the CD4+, CD8+, and CD3+ T‐cell subpopulations by cytofluorometry in LSCC patients. A cohort of healthy patients was used as control group. The disease‐specific survival (DSS) was considered as survival outcome. Results: Sixty‐five LSCC patients and 48 controls were enrolled. In LSCC patients, neutrophils were higher than in the healthy group (P < .0001). The neutrophil‐to‐lymphocyte ratio (NLR) and the platelet‐to‐lymphocyte ratio (PLR) were both higher in LSCC patients (P < .0001). In patients treated for recurrent disease, the CD8+/CD3+ ratio was increased (P =.02), while the CD4+/CD8+ (P =.03) and CD4+/CD3+ (P =.04) ratios were lower. In patients with lymph node metastases, leukocytes (P =.03), CD3+ (P =.04), and CD4+ (P =.0098) were all higher. Among Stages III‐IV patients, low lymphocyte and low leukocyte count were associated with worse DSS. Conclusion: Our data demonstrate that NLR and PLR are significantly increased in LSCC. Lower CD4+/CD8+ and CD3+/CD8+ ratios are related to recurrent disease and a higher level of CD3+ and CD4+ is associated with nodal metastasis. Level of Evidence: 4
- Subjects
NEUTROPHILS; SQUAMOUS cell carcinoma; BLOOD cell count; LYMPHOCYTE count; LEUKOCYTE count; T cells
- Publication
Laryngoscope Investigative Otolaryngology, 2019, Vol 4, Issue 5, p513
- ISSN
2378-8038
- Publication type
Article
- DOI
10.1002/lio2.304