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- Title
Adaptive Monitoring of Biotechnological Processes Kinetics.
- Authors
Lyubenova, Velislava; Ignatova, Maya; Roeva, Olympia; Junne, Stefan; Neubauer, Peter
- Abstract
In this paper, an approach for the monitoring of biotechnological process kinetics is proposed. The kinetics of each process state variable is presented as a function of two time-varying unknown parameters. For their estimation, a general software sensor is derived with on-line measurements as inputs that are accessible in practice. The stability analysis with a different number of inputs shows that stability can be guaranteed for fourth- and fifth-order software sensors only. As a case study, the monitoring of the kinetics of processes carried out in stirred tank reactors is investigated. A new tuning procedure is derived that results in a choice of only one design parameter. The effectiveness of the proposed procedure is demonstrated with experimental data from Bacillus subtilis fed-batch cultivations.
- Subjects
BIOTECHNOLOGICAL process monitoring; ANALYTICAL mechanics; BACILLUS subtilis
- Publication
Processes, 2020, Vol 8, Issue 10, p1307
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr8101307