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- Title
Reactivation of Herpes Simplex Virus Type 1 (HSV-1) Detected on Bronchoalveolar Lavage Fluid (BALF) Samples in Critically Ill COVID-19 Patients Undergoing Invasive Mechanical Ventilation: Preliminary Results from Two Italian Centers.
- Authors
Giacobbe, Daniele Roberto; Di Bella, Stefano; Dettori, Silvia; Brucci, Giorgia; Zerbato, Verena; Pol, Riccardo; Segat, Ludovica; D'Agaro, Pierlanfranco; Roman-Pognuz, Erik; Friso, Federica; Principe, Luigi; Lucangelo, Umberto; Ball, Lorenzo; Robba, Chiara; Battaglini, Denise; De Maria, Andrea; Brunetti, Iole; Patroniti, Nicolò; Briano, Federica; Bruzzone, Bianca
- Abstract
Reactivation of herpes simplex virus type 1 (HSV-1) has been described in critically ill patients with coronavirus disease 2019 (COVID-19) pneumonia. In the present two-center retrospective experience, we primarily aimed to assess the cumulative risk of HSV-1 reactivation detected on bronchoalveolar fluid (BALF) samples in invasively ventilated COVID-19 patients with worsening respiratory function. The secondary objectives were the identification of predictors for HSV-1 reactivation and the assessment of its possible prognostic impact. Overall, 41 patients met the study inclusion criteria, and 12/41 patients developed HSV-1 reactivation (29%). No independent predictors of HSV-1 reactivation were identified in the present study. No association was found between HSV-1 reactivation and mortality. Eleven out of 12 patients with HSV-1 reactivation received antiviral therapy with intravenous acyclovir. In conclusion, HSV-1 reactivation is frequently detected in intubated patients with COVID-19. An antiviral treatment in COVID-19 patients with HSV-1 reactivation and worsening respiratory function might be considered.
- Subjects
HUMAN herpesvirus 1; COVID-19; HERPES simplex virus; HEPATITIS B virus; BRONCHOALVEOLAR lavage; CRITICALLY ill; ARTIFICIAL respiration; COVID-19 treatment
- Publication
Microorganisms, 2022, Vol 10, Issue 2, pN.PAG
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10020362