We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bosutinib: Pediatric First Approval.
- Authors
Hoy, Sheridan M.
- Abstract
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., is well established in the EU and the USA as a treatment for adults with newly diagnosed (ND) chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML), and for CP, accelerated phase and blast phase Ph+ CML that is resistant or intolerant (R/I) to prior therapy. In September 2023, based on clinical data from patients aged ≥ 1 to < 18 years, bosutinib was approved in the USA for the treatment of pediatric patients aged ≥ 1 year with CP Ph+ CML that is ND or R/I to prior therapy. This article summarizes the milestones in the development of bosutinib leading to this first pediatric approval.
- Subjects
OLDER patients; CHILD patients; PFIZER Inc.; CHRONIC myeloid leukemia; PROTEIN-tyrosine kinase inhibitors; PEDIATRIC therapy
- Publication
Pediatric Drugs, 2024, Vol 26, Issue 2, p209
- ISSN
1174-5878
- Publication type
Article
- DOI
10.1007/s40272-023-00608-4