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- Title
The Distribution Clinical and Demographic Features of HBsAg Positive Patients in Şanlıurfa Region.
- Authors
UYANIKOĞLU, Ahmet; SERT, Umut; ÇETİN, Burcu; UYANIKOĞLU, Hacer; YENİCE, Necati
- Abstract
Objective: The objective of this study was to investigate the distribution of the clinic and demographic characteristics of hepatitis b surface antigen (HBsAg) positive patients in Şanlıurfa region. Materials and Methods: HBsAg seropositive patients admitted to the gastroenterology outpatient clinics were classified as inactive carriers, chronic hepatitis B (CHB), hepatitis B virus (HBV) cirrhosis, chronic hepatitis delta and cirrhosis. Demographic and clinical features of the patients and antiviral treatment they received were analyzed. Results: HBsAg seropositivity was detected in 296 patients (mean age: 38.8±13.7 years, range: 15-74), 152 patients (51%) were male (mean age: 38.5±14.4 years, range: 15-73) and 144 (49%) were female (mean age: 39.1±13.7 years, range: 15-74). Two hundred five patients (69%) were detected to be inactive HBV carriers (mean age: 37.7±12.9 years, range: 15-74) and 91 (44.4%) of them were male. CHB was detected in 44(16%) patients (mean age: 36.7±13.4 years, range: 17-69) and 27 (60%) were male. Cirrhosis was detected in 30 (10%) patients (mean age: 49±15 years, range: 20-73) and 24 (83%) were male. Seventeen patients (5%) (mean age: 37.8±12.8 years, range: 16-60) were antihepatitis D virus (anti-HDV) positive, 11 (65%) were male, 5 of them were in the cirrhotic stage. Two patients (0.6%) had HBV/HCV coinfection, two patients (0.6%) had hepatocellular carcinoma (HCC). Seven patients were pregnant, three patients were given tenofovir in the 3rd trimester, due to high viral load. Seventy one of 73 (26%) patients who were identified to have cirrhosis or chronic hepatitis due to HBV or HDV, 71 of (those who received or completed interferon treatment) received antiviral therapy, most commonly tenofovir. Liver transplantation was performed in two patients (0.6%) due to HBV related liver cirrhosis. Conclusion: Three-quarters HBsAg seropositive patients in Şanlıurfa region were inactive HBV carriers and one quarter were at the stage of chronic hepatitis or cirrhosis. Inactive carriers and chronic hepatitis patients are often in the 3rd decade and cirrhotic patients were in the 4th decade of life. Chronic HDV was observed in 5% of patients, HBV related HCC 0.6%, HBV/HCV co-infection was found in 0.6% of patients. Almost all patients with chronic hepatitis or cirrhosis were found to be received or/receiving antiviral treatment and the most commonly used medication was tenofovir.
- Subjects
TURKEY; HEPATITIS B; VIRAL antigens; ANTIVIRAL agents; CIRRHOSIS of the liver; HEPATITIS C; DESCRIPTIVE statistics; SOCIODEMOGRAPHIC factors; CARRIER state (Communicable diseases); LIVER transplantation; HEPATITIS D; ANTIGENS; HEPATOCELLULAR carcinoma; CHRONIC hepatitis B; SYMPTOMS
- Publication
Viral Hepatitis Journal / Viral Hepatit Dergisi, 2015, Vol 21, Issue 3, p89
- ISSN
1307-9441
- Publication type
Article
- DOI
10.4274/vhd.54227