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- Title
Effects of NAD+ in Caenorhabditis elegans Models of Neuronal Damage.
- Authors
Lee, Yuri; Jeong, Hyeseon; Park, Kyung Hwan; Kim, Kyung Won
- Abstract
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NAD+ biosynthetic enzymes and NAD+-consuming enzymes are involved in neuroprotection and axon regeneration. The nematode Caenorhabditis elegans has served as a model to study the neuronal role of NAD+ because many molecular components regulating NAD+ are highly conserved. This review focuses on recent findings using C. elegans models of neuronal damage pertaining to the neuronal functions of NAD+ and its precursors, including a neuroprotective role against excitotoxicity and axon degeneration as well as an inhibitory role in axon regeneration. The regulation of NAD+ levels could be a promising therapeutic strategy to counter many neurodegenerative diseases, as well as neurotoxin-induced and traumatic neuronal damage.
- Subjects
NAD (Coenzyme); DAMAGE models; CAENORHABDITIS elegans; CAENORHABDITIS; NEURODEGENERATION; NICOTINAMIDE; AXONS; DEGENERATION (Pathology)
- Publication
Biomolecules (2218-273X), 2020, Vol 10, Issue 7, p993
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom10070993