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- Title
Efficacy of ketoprofen lysine salt and paracetamol/acetaminophen to reduce pain during rapid maxillary expansion: A randomized controlled clinical trial.
- Authors
Cossellu, Gianguido; Lanteri, Valentina; Lione, Roberta; Ugolini, Alessandro; Gaffuri, Francesca; Cozza, Paola; Farronato, Marco
- Abstract
Summary: Background: Rapid maxillary expansion (RME) is an orthopaedic procedure indicated for a wide variety of clinical conditions. Aim: The aim of the study was to compare the effects of ketoprofen lysine salt (KLS) vs paracetamol/acetaminophen (P) on pain perception during RME. Design: One hundred and fifty‐one subjects (mean age 8.6 year) were enrolled in this prospective controlled clinical trial according to inclusion criteria: prepuberal stage of development, negative posterior transverse interarch discrepancy, non‐concurrent use of other drugs. First phase: n.40 allocated to Group 1 used 40 mg of KLS, n.40 to Group 2 used 250 mg of P, n.36 to Group 3 as control group. Second phase: n.35 allocated to Group 4 used 40 mg ketoprofen lysine salt once a day for the first 3 days of activation. Pain experience was reported on a numeric rating scale (0‐4) and a 100‐mm visual analogue scale. Pain perception was tested with the Mann‐Whitney test (P < 0.05). Results: Pain perception was higher during the first 3 days of activation and it was described as mild to moderate. Group 1 experienced significantly less pain during the fourth, fifth, and sixth day (P < 0.05) compared with Group 2. Patients of the Group 4 reported significantly lower pain during the whole period of RME activation (P < 0.05). Conclusions: The perceived higher pain was reported during the second and third day of expansion. The analgesic effect of KLS is more effective than P during the fourth, fifth, and sixth day. The use of KLS during the first 3 days of activation seems to be able reducing pain during the whole active phase.
- Subjects
NONSTEROIDAL anti-inflammatory agents; PHYSIOLOGICAL effects of lysine; ACETAMINOPHEN-hydrocodone (Drug); ANALGESICS; MAXILLA; CORRECTIVE orthodontics; ORTHOPEDIC surgery; TOOTHACHE; PAIN measurement; TREATMENT effectiveness; MANN Whitney U Test; THERAPEUTICS
- Publication
International Journal of Paediatric Dentistry, 2019, Vol 29, Issue 1, p58
- ISSN
0960-7439
- Publication type
Article
- DOI
10.1111/ipd.12428