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- Title
GLICOPEPTÍDEOS: ASPECTOS FARMACOLÓGICOS E APLICAÇÕES CLÍNICAS.
- Authors
Castro de Matos, Brenda; Barbosa da Silva, Yasmin Castilho; Andrade Burton, Elizianne; Magalhães de Oliveira, Mírian Brasil; Alves Manaças, Liliane Rosa; Caribé Badin, Rebeka
- Abstract
The indiscriminate use of antimicrobials has generated a significant problem in public health, causing negative impacts such as failure in pharmacotherapy against bacterial infections and increases in healthcare costs. This narrative review aims to describe the pharmacokinetic and pharmacodynamic properties and clinical applications of the main antibiotics belonging to the class of glycopeptides. The search for articles was carried out in the following databases: Latin American and Caribbean Literature in Health Sciences (LILACS/PUBMED), SciELO (Scientific Electronic Library Online), and Virtual Health Library (BVS). Vancomycin and teicoplanin are firstline drugs in infections caused by gram-positive bacteria it resistant to other antibiotics. Both have complex cyclic structures containing amino acids linked to carbohydrate groups that give them unique properties. The administration of glycopeptides must consider patient-related factors such as age group, renal function, malnutrition, and obesity due to its pharmacokinetic heterogeneity. Therefore, serum monitoring is recommended to ensure effective plasma concentrations. Thus, the proper use based on scientific evidence of this important class of antibiotics aims to optimize pharmacotherapeutic treatment and reduce the progress of bacterial resistance.
- Publication
Arquivos de Ciências da Saúde da UNIPAR, 2023, Vol 27, Issue 10, p5863
- ISSN
1415-076X
- Publication type
Article
- DOI
10.25110/arqsaude.v27i10.2023-026