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- Title
ESCITALOPRAM AND MIRTAZAPINE FOR THE TREATMENT OF DEPRESSION IN HIV PATIENTS: A RANDOMIZED CONTROLLED OPEN LABEL TRIAL.
- Authors
Patel, Shanti; Kukreja, Sanjay; Atram, Umesh; Sousa, Avinash De; Shah, Nilesh; Yadav, Sameer; Sonavane, Sushma
- Abstract
Objective: The objective of this study was to compare the safety and efficacy of mirtazapine and escitalopram in HIV patients for the treatment of depression. Methods: In this trial, 70 adult HIV patients with major depression were randomized and assigned to receive 8 weeks of daily open label mirtazapine (5-30 mg) or escitalopram (7.5-20 mg). The primary outcome variables were endpoint response in Hamilton Rating Scale for Depression (HAM-D) score and change of HAM-D score from baseline to endpoint. Patients having improvement of > 50% on the HAM-D total scores during treatment were considered to have responded. A final 17-item HAM-D total score of 8 or less defined remission. Results: The response rate was 91.4 % (32/35) in Mirtazapine group and 85.7 % (30/35) in Escitalopram group (p= 0.71). The remission rate was more in escitalopram group (48.6 %, 17/35) compared to Mirtazapine group (34.3 %, 12/35); however it was not statistically significant (Chi square (1, N = 70) = 2.1, p = 0.22). After controlling for baseline score, the median HAMD score at 8 weeks was significantly lower in the Mirtazapine group (Median (Mdn)=4, Interquartile range (IQR)= 11) compared to Escitalopram group (Mdn=13, IQR= 12) (p < 0.001). The number of adverse events reported was more in Escitalopram group (110) than Mirtazapine group (85); however this was not statistically significant (p= 0.34). Conclusions: Both these drugs are useful in the management of depression in HIV patients and need further study.
- Subjects
MENTAL depression; DEPRESSED persons; MIRTAZAPINE; ADRENERGIC alpha blockers; ANTIDEPRESSANTS
- Publication
ASEAN Journal of Psychiatry, 2013, Vol 14, Issue 1, p1
- ISSN
2231-7805
- Publication type
Article