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- Title
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
- Authors
Fuller, Peter J.; Alexiadis, Maria; Jobling, Tom; McNeilage, Jane
- Abstract
The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pituitary hormone stimulation and synthesize steroid hormones. To test the hypothesis that seladin-1 may also have a role in the pathogenesis of GCT, we determined the expression of seladin-1 in a cohort of GCT and in mucinous and serous cystadenocarcinomas and in normal ovary. Expression was determined by RT-PCR using gene specific primers and probes combined with Southern blot analysis of the PCR products. Seladin-1 expression was identified in the normal ovary, mucinous cystadenocarcinomas and serous cystadenocarcinomas of the ovary whereas no expression was observed in the GCT. Based on our results, seladin-1 is not expressed in the granulosa cells or at least not in those that give rise to GCT.
- Subjects
ADENOMA; GRANULOSA cell tumors; POLYMERASE chain reaction; STEROID hormones; GENES; EPITHELIAL cells
- Publication
Clinical Endocrinology, 2005, Vol 63, Issue 1, p111
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/j.1365-2265.2005.02308.x