We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation.
- Authors
Roberts, Graham A.; Holt, Richard I. G.; Ghatei, Mohammed A.; Baker, Alastair J.; Bloom, Stephen R.; Miell, John P.
- Abstract
OBJECTIVELeptin, the product of the ob gene, is a postulated feedback regulator of adiposity with appetite suppressant and catabolic effects. Catabolic states are associated with decreased body fat mass as a result of both nutritional and metabolic perturbation. Low serum leptin has been described previously in a number of catabolic states. It has been unclear whether the observed changes in leptin are a cause or consequence of changes in adiposity. Paediatric end-stage liver disease (ESLD) is characterized by decreased body fat mass and poor linear growth. Successful treatment by orthotopic liver transplantation (OLT) is accompanied by increase in fat mass. We investigated the hypothesis that serum leptin would be low in paediatric ESLD and that increase in body fat mass post-OLT would result in increased serum leptin. DESIGNSerum leptin and insulin were measured by radioimmunoassay in children with ESLD before and after successful OLT and in age-matched controls. PATIENTSTwenty-four children with ESLD attending the outpatient department of King's College Hospital, London and 10 age-matched controls. MEASUREMENTSAnthropometric measurements were performed according to standard techniques and standard deviation (SDS) derived from population standards. Serum leptin and insulin were measured by radioimmunoassay. RESULTSSerum leptin pre-OLT, leptin (4.06 μg/l, [3.45, 5.68] median, with 25th and 75th interquartile ranges) was significantly lower than controls (6.62 μg/l, [4.33, 8.05], P = 0.02). Following OLT, serum leptin fell to levels which were significantly lower than pre-OLT values (3.32 μg/l, [2.30, 3.99], P = 0.01). There was no significant difference between boys and girls either pre-OLT (boys; 3.64 μg/l, [2.45, 5.57], girls; 4.14 μg/l, [3.18, 5.65]) or post-OLT (boys; 3.32 μg/l, [2.93, 3.62], girls; 3.69 μg/l, [2.23, 4.63]. Neither the age at OLT nor the age at the time of blood sampling was correlated with serum leptin...
- Subjects
LEPTIN; OBESITY; METABOLIC disorders
- Publication
Clinical Endocrinology, 1998, Vol 48, Issue 4, p401
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1046/j.1365-2265.1998.00448.x