OpenURL Connection Search

Select item for more details and to access through your institution.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.
Published in:
Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-020-01109-y
By:
- Bury, Joanna J.;
- Chambers, Annabelle;
- Heath, Paul R.;
- Ince, Paul G.;
- Shaw, Pamela J.;
- Matthews, Fiona E.;
- Brayne, Carol;
- Simpson, Julie E.;
- Wharton, Stephen B.
Publication type:
Article
Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-01009-1
By:
- MacGregor Sharp, Matthew;
- Saito, Satoshi;
- Keable, Abby;
- Gatherer, Maureen;
- Aldea, Roxana;
- Agarwal, Nivedita;
- Simpson, Julie E.;
- Wharton, Stephen B.;
- Weller, Roy O.;
- Carare, Roxana O.
Publication type:
Article
Inflammation in the central nervous system in multiple sclerosis: The role of chemokines and their receptors.
Published in:
Inflammopharmacology, 2001, v. 9, n. 1/2, p. 23, doi. 10.1163/156856001300248290
By:
- Simpson, Julie E.;
- Woodroofe, M. Nicola
Publication type:
Article
Hypoxia‐induced changes in microglia in the vhl‐/‐ zebrafish: Developing topics.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047129
By:
- Almasnouri, Taghreed S;
- Hamilton, Noémie;
- Heath, Paul;
- van Eeden Van Eeden, Freek;
- Simpson, Julie E
Publication type:
Article
S5‐01‐01: AGEING AND NEUROIMMUNOLOGY: WHITE MATTER PATHOLOGY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1624, doi. 10.1016/j.jalz.2018.06.2964
By:
- Simpson, Julie E.;
- Wharton, Stephen;
- Brayne, Carol;
- Matthews, Fiona;
- Heath, Paul;
- Ince, Paul
Publication type:
Article
P4‐059: NEUTROPHIL‐DERIVED MICROVESICLE‐INDUCED BLOOD BRAIN BARRIER DYSFUNCTION: A POTENTIAL MECHANISM LINKING SYSTEMIC INFLAMMATION AND DEMENTIA.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1455, doi. 10.1016/j.jalz.2018.06.2462
By:
- Ajikumar, Anjana;
- Ridger, Victoria;
- Heath, Paul;
- Wharton, Stephen;
- Ince, Paul;
- Simpson, Julie E.
Publication type:
Article
Potential Mechanisms Underlying the Dysfunction of the Blood–Brain Barrier.
Published in:
2023
By:
- Simpson, Julie E.
Publication type:
Editorial
RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer's Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 5913, doi. 10.3390/ijms23115913
By:
- Vázquez-Villaseñor, Irina;
- Smith, Cynthia I.;
- Thang, Yung J. R.;
- Heath, Paul R.;
- Wharton, Stephen B.;
- Blackburn, Daniel J.;
- Ridger, Victoria C.;
- Simpson, Julie E.
Publication type:
Article
Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 8028, doi. 10.3390/ijms21218028
By:
- Allen, Scott P.;
- Seehra, Rajpinder Singh;
- Heath, Paul R.;
- Hall, Benjamin P. C.;
- Bates, Jessica;
- Garwood, Claire J.;
- Matuszyk, Martyna M.;
- Wharton, Stephen B.;
- Simpson, Julie E.
Publication type:
Article
Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 7924, doi. 10.3390/ijms21217924
By:
- Fadul, Motaz M.;
- Heath, Paul R.;
- Cooper-Knock, Johnathan;
- Kurz, Julian M.;
- Al-Azzawi, Hayder A.;
- Ali, Zarki;
- Smith, Taylor;
- Matthews, Fiona E.;
- Brayne, Carol;
- Wharton, Stephen B.;
- Simpson, Julie E.
Publication type:
Article
The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 4, p. 1225, doi. 10.3390/ijms21041225
By:
- Owasil, Raisah;
- O'Neill, Ronan;
- Keable, Abby;
- Nimmo, Jacqui;
- MacGregor Sharp, Matthew;
- Kelly, Louise;
- Saito, Satoshi;
- Simpson, Julie E.;
- Weller, Roy O.;
- Smith, Colin;
- Attems, Johannes;
- Wharton, Stephen B.;
- Yuen, Ho Ming;
- Carare, Roxana O.
Publication type:
Article
NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 1, p. 340, doi. 10.3390/ijms21010340
By:
- Fadul, Motaz M.;
- Garwood, Claire J.;
- Waller, Rachel;
- Garrett, Navonna;
- Heath, Paul R.;
- Matthews, Fiona E;
- Brayne, Carol;
- Wharton, Stephen B.;
- Simpson, Julie E.
Publication type:
Article
Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 5227, doi. 10.3390/ijms20205227
By:
- Ajikumar, Anjana;
- Long, Merete B.;
- Heath, Paul R.;
- Wharton, Stephen B.;
- Ince, Paul G.;
- Ridger, Victoria C.;
- Simpson, Julie E.
Publication type:
Article
Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 12, p. 3097, doi. 10.3390/ijms20123097
By:
- Goodall, Emily F.;
- Leach, Vicki;
- Wang, Chunfang;
- Cooper-Knock, Johnathan;
- Heath, Paul R.;
- Baker, David;
- Drew, David R.;
- Saffrey, M. Jill;
- Simpson, Julie E.;
- Romero, Ignacio A.;
- Wharton, Stephen B.
Publication type:
Article
Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain.
Published in:
Glia, 2018, v. 66, n. 11, p. 2316, doi. 10.1002/glia.23465
By:
- Waller, Rachel;
- Murphy, Mark;
- Garwood, Claire J;
- Jennings, Luke;
- Heath, Paul R;
- Chambers, Annabelle;
- Matthews, Fiona E;
- Brayne, Carol;
- Ince, Paul G;
- Wharton, Stephen B;
- Simpson, Julie E
Publication type:
Article
Alpha-synuclein mRNA expression in oligodendrocytes in MSA.
Published in:
Glia, 2014, v. 62, n. 6, p. 964, doi. 10.1002/glia.22653
By:
- Asi, Yasmine T.;
- Simpson, Julie E.;
- Heath, Paul R.;
- Wharton, Stephen B.;
- Lees, Andrew J.;
- Revesz, Tamas;
- Houlden, Henry;
- Holton, Janice L.
Publication type:
Article
A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment.
Published in:
PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0118463
By:
- Mathur, Ryan;
- Ince, Paul G.;
- Minett, Thais;
- Garwood, Claire J.;
- Shaw, Pamela J.;
- Matthews, Fiona E.;
- Brayne, Carol;
- Simpson, Julie E.;
- Wharton, Stephen B.;
- null, null
Publication type:
Article
Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer's disease research.
Published in:
Journal of Neurochemistry, 2022, v. 160, n. 4, p. 434, doi. 10.1111/jnc.15538
By:
- Matuszyk, Martyna M.;
- Garwood, Claire J.;
- Ferraiuolo, Laura;
- Simpson, Julie E.;
- Staniforth, Rosemary A.;
- Wharton, Stephen B.
Publication type:
Article
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2015, v. 35, n. 3, p. 412, doi. 10.1038/jcbfm.2014.207
By:
- Wu, Dongsheng;
- Cerutti, Camilla;
- Lopez-Ramirez, Miguel A;
- Pryce, Gareth;
- King-Robson, Josh;
- Simpson, Julie E;
- van der Pol, Susanne MA;
- Hirst, Mark C;
- de Vries, Helga E;
- Sharrack, Basil;
- Baker, David;
- Male, David K;
- Michael, Gregory J;
- Romero, Ignacio A
Publication type:
Article
Insights into the pathological basis of dementia from population‐based neuropathology studies.
Published in:
Neuropathology & Applied Neurobiology, 2023, v. 49, n. 4, p. 1, doi. 10.1111/nan.12923
By:
- Wharton, Stephen B.;
- Simpson, Julie E.;
- Ince, Paul G.;
- Richardson, Connor D.;
- Merrick, Richard;
- Matthews, Fiona E.;
- Brayne, Carol
Publication type:
Article
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
Published in:
Neuropathology & Applied Neurobiology, 2016, v. 42, n. 2, p. 167, doi. 10.1111/nan.12252
By:
- Simpson, Julie E.;
- Ince, Paul G.;
- Minett, Thais;
- Matthews, Fiona E.;
- Heath, Paul R.;
- Shaw, Pamela J.;
- Goodall, Emily;
- Garwood, Claire J.;
- Ratcliffe, Laura E.;
- Brayne, Carol;
- Rattray, Magnus;
- Wharton, Stephen B.
Publication type:
Article
A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.
Published in:
Neuropathology & Applied Neurobiology, 2015, v. 41, n. 4, p. 483, doi. 10.1111/nan.12202
By:
- Simpson, Julie E.;
- Ince, Paul G.;
- Matthews, Fiona E.;
- Shaw, Pamela J.;
- Heath, Paul R.;
- Brayne, Carol;
- Garwood, Claire;
- Higginbottom, Adrian;
- Wharton, Stephen B.
Publication type:
Article
DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study ( MRC- CFAS) cohort.
Published in:
Neuropathology & Applied Neurobiology, 2014, v. 40, n. 7, p. 802, doi. 10.1111/nan.12156
By:
- Garwood, Claire J.;
- Simpson, Julie E.;
- Al Mashhadi, Sufana;
- Axe, Claire;
- Wilson, Suzanna;
- Heath, Pamela R.;
- Shaw, Pamela J.;
- Matthews, Fiona E.;
- Brayne, Carol;
- Ince, Paul G.;
- Wharton, Stephen B.
Publication type:
Article
MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.
Published in:
FASEB Journal, 2014, v. 28, n. 6, p. 2551, doi. 10.1096/fj.13-248880
By:
- Lopez-Ramirez, Miguel Alejandro;
- Dongsheng Wu;
- Pryce, Gareth;
- Simpson, Julie E.;
- Reijerkerk, Arie;
- King-Robson, Josh;
- Kay, Oliver;
- de Vries, Helga E.;
- Hirst, Mark C.;
- Sharrack, Basil;
- Baker, David;
- Kingsley Male, David;
- Michael, Gregory J.;
- Romero, Ignacio Andres
Publication type:
Article
Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function.
Published in:
European Journal of Neuroscience, 2021, v. 54, n. 9, p. 6987, doi. 10.1111/ejn.15466
By:
- Vazquez‐Villasenor, Irina;
- Garwood, Claire J.;
- Simpson, Julie E.;
- Heath, Paul R.;
- Mortiboys, Heather;
- Wharton, Stephen B.
Publication type:
Article
Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes.
Published in:
European Journal of Neuroscience, 2018, v. 47, n. 12, p. 1444, doi. 10.1111/ejn.13933
By:
- Morgan, Sarah V.;
- Garwood, Claire J.;
- Jennings, Luke;
- Simpson, Julie E.;
- Castelli, Lydia M.;
- Heath, Paul R.;
- Mihaylov, Simeon R.;
- Vaquéz‐Villaseñor, Irina;
- Minshull, Thomas C.;
- Ince, Paul G.;
- Dickman, Mark J.;
- Hautbergue, Guillaume M.;
- Wharton, Stephen B.
Publication type:
Article
Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke.
Published in:
Brain Pathology, 2022, v. 32, n. 6, p. 1, doi. 10.1111/bpa.13101
By:
- Hase, Yoshiki;
- Ameen‐Ali, Kamar E.;
- Waller, Rachel;
- Simpson, Julie E.;
- Stafford, Charlotte;
- Mahesh, Ayushi;
- Ryan, Lucy;
- Pickering, Lucy;
- Bodman, Caroline;
- Hase, Mai;
- Boche, Delphine;
- Horsburgh, Karen;
- Wharton, Stephen B.;
- Kalaria, Raj N.
Publication type:
Article
Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.
Published in:
Brain Pathology, 2021, v. 31, n. 3, p. 1, doi. 10.1111/bpa.12928
By:
- Waller, Rachel;
- Narramore, Ruth;
- Simpson, Julie E.;
- Heath, Paul R.;
- Verma, Nikita;
- Tinsley, Megan;
- Barnes, Jordan R.;
- Haris, Hanna T.;
- Henderson, Frances E.;
- Matthews, Fiona E.;
- Richardson, Connor D.;
- Brayne, Carol;
- Ince, Paul G.;
- Kalaria, Raj N.;
- Wharton, Stephen B.
Publication type:
Article
Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.
Published in:
Brain Pathology, 2015, v. 25, n. 5, p. 565, doi. 10.1111/bpa.12216
By:
- Al‐Mashhadi, Sufana;
- Simpson, Julie E.;
- Heath, Paul R.;
- Dickman, Mark;
- Forster, Gillian;
- Matthews, Fiona E.;
- Brayne, Carol;
- Ince, Paul G.;
- Wharton, Stephen B.
Publication type:
Article
Age-Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study.
Published in:
Brain Pathology, 2015, v. 25, n. 1, p. 35, doi. 10.1111/bpa.12219
By:
- Wharton, Stephen B.;
- Simpson, Julie E.;
- Brayne, Carol;
- Ince, Paul G.
Publication type:
Article
Cerebellar degeneration in gluten ataxia is linked to microglial activation.
Published in:
Brain Communications, 2024, v. 6, n. 2, p. 1, doi. 10.1093/braincomms/fcae078
By:
- Floare, Mara-Luciana;
- Wharton, Stephen B;
- Simpson, Julie E;
- Aeschlimann, Daniel;
- Hoggard, Nigel;
- Hadjivassiliou, Marios
Publication type:
Article
Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.
Published in:
Molecular Brain, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13041-015-0138-6
By:
- Garwood, Claire J.;
- Ratcliffe, Laura E.;
- Morgan, Sarah V.;
- Simpson, Julie E.;
- Owens, Helen;
- Vazquez-Villaseñor, Irina;
- Heath, Paul R.;
- Romero, Ignacio A.;
- Ince, Paul G.;
- Wharton, Stephen B.
Publication type:
Article
Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.
Published in:
Molecular Brain, 2015, v. 8, n. 1, p. 51, doi. 10.1186/s13041-015-0138-6
By:
- Garwood, Claire J.;
- Ratcliffe, Laura E.;
- Morgan, Sarah V.;
- Simpson, Julie E.;
- Owens, Helen;
- Vazquez-Villaseñor, Irina;
- Heath, Paul R.;
- Romero, Ignacio A.;
- Ince, Paul G.;
- Wharton, Stephen B.
Publication type:
Article
Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions.
Published in:
PLoS ONE, 2019, v. 14, n. 1, p. 1, doi. 10.1371/journal.pone.0210888
By:
- Waller, Rachel;
- Baxter, Lynne;
- Fillingham, Daniel J.;
- Coelho, Santiago;
- Pozo, Jose M.;
- Mozumder, Meghdoot;
- Frangi, Alejandro F.;
- Ince, Paul G.;
- Simpson, Julie E.;
- Highley, J. Robin
Publication type:
Article
The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 8, p. 4445, doi. 10.3390/ijms25084445
By:
- Almansouri, Taghreed;
- Waller, Rachel;
- Wharton, Stephen B.;
- Heath, Paul R.;
- Matthews, Fiona E.;
- Brayne, Carol;
- van Eeden, Fredericus;
- Simpson, Julie E.
Publication type:
Article
Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex.
Published in:
Neuropathology, 2020, v. 40, n. 4, p. 336, doi. 10.1111/neup.12649
By:
- Waller, Rachel;
- Mandeya, Memory;
- Viney, Edward;
- Simpson, Julie E.;
- Wharton, Stephen B.
Publication type:
Article

Found: 36

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.

Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia.

Inflammation in the central nervous system in multiple sclerosis: The role of chemokines and their receptors.

Hypoxia‐induced changes in microglia in the vhl<sup>‐/‐</sup> zebrafish: Developing topics.

S5‐01‐01: AGEING AND NEUROIMMUNOLOGY: WHITE MATTER PATHOLOGY.

P4‐059: NEUTROPHIL‐DERIVED MICROVESICLE‐INDUCED BLOOD BRAIN BARRIER DYSFUNCTION: A POTENTIAL MECHANISM LINKING SYSTEMIC INFLAMMATION AND DEMENTIA.

Potential Mechanisms Underlying the Dysfunction of the Blood–Brain Barrier.

RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer's Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity.

Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response.

Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response.

The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy.

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro.

Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier.

Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain.

Alpha-synuclein mRNA expression in oligodendrocytes in MSA.

A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment.

Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer's disease research.

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.

Insights into the pathological basis of dementia from population‐based neuropathology studies.

Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort.

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study ( MRC- CFAS) cohort.

MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.

Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function.

Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes.

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke.

Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies.

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain.

Age-Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study.

Cerebellar degeneration in gluten ataxia is linked to microglial activation.

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.

Iba-1<sup>-</sup>/CD68<sup>+</sup> microglia are a prominent feature of age-associated deep subcortical white matter lesions.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex.