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- Title
Uremic pruritus and serum brain-derived neurotrophic factor in diabetic and non-diabetic haemodialysis patients.
- Authors
Śnit, Mirosław; Nabrdalik, Katarzyna; Gawlik, Radosław; Wystrychowski, Grzegorz; Łącka-Gaździk, Beata; Kuźniewicz, Roman; Gumprecht, Janusz; Wielkoszyński, Tomasz; Łabuz-Roszak, Beata; Grzeszczak, Władysław
- Abstract
Introduction: Even though uremic pruritus (UP) is very troublesome for haemodialysis (HD) patients, its underlying mechanism is not fully understood. Aim: Due to the possible role of brain-derived neurotrophic factor (BDNF) and its higher serum concentration in haemodialysis diabetic patients compared to non-diabetic ones, this study is aimed to evaluate its association with UP among diabetic and non-diabetic patients on maintenance HD. Material and methods: A total of 94 patients were enrolled into the study. A visual analogue scale (VAS) was used to assess pruritus. Results: No differences were found between the observed study groups in terms of BDNF serum concentration, other biochemical markers, sleep disturbances, or pruritus presentation. Conclusions: BDNF serum concentration was not found to be associated with UP among HD patients, however further studies are worth performing on a larger group of individuals.
- Subjects
HEMOLYTIC-uremic syndrome; SERUM; HEMODIALYSIS; VISUAL analog scale; BRAIN-derived neurotrophic factor
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2020, Vol 37, Issue 6, p932
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/ada.2019.87707