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- Title
Serglycin proteoglycan in hematologic malignancies: a marker of acute myeloid leukemia.
- Authors
Niemann, C. U.; Kjeldsen, L.; Ralfkiaer, E.; Jensen, M. K.; Borregaard, N.
- Abstract
Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.Leukemia (2007) 21, 2406–2410; doi:10.1038/sj.leu.2404975; published online 11 October 2007
- Subjects
PROTEOGLYCANS; PEPTIDOGLYCANS; BACTERIAL cell walls; MICROBIAL polysaccharides; MYELOID leukemia; BONE marrow diseases
- Publication
Leukemia (08876924), 2007, Vol 21, Issue 12, p2406
- ISSN
0887-6924
- Publication type
Article
- DOI
10.1038/sj.leu.2404975