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- Title
Pure red cell aplasia caused by B19 parvovirus infection after autologous blood stem cell transplantation in a patient with chronic lymphocytic leukemia.
- Authors
Itälä, M; Kotilainen, P; Nikkari, S; Remes, K; Nikoskelainen, J
- Abstract
We describe a patient with acute promyelocytic leukemia (APL) who was successfully induced into remission with all-trans retinoic acid (ATRA) and idarubicin, but developed myelodysplastic syndrome (MDS) with monosomy 7 shortly after conclusion of maintenance therapy with idarubicin alternating with 6-mercaptopurine, vincristine, methotrexate and prednisone. Patients on combination regimens of ATRA or other retinoids and chemotherapy, which are being increasingly used in recent years, should be closely monitored for the development of potentially new complications including MDS.
- Subjects
LEUKEMIA; TRETINOIN; ANTINEOPLASTIC agents; CHRONIC lymphocytic leukemia treatment; APLASTIC anemia; COMBINED modality therapy; HEMATOPOIETIC stem cell transplantation; IMMUNOSUPPRESSION; PARVOVIRUS diseases; VIRUSES; DISEASE complications
- Publication
Leukemia (08876924), 1997, Vol 11, Issue 1, p171
- ISSN
0887-6924
- Publication type
case study