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- Title
Dexamethasone-Cyclophosphamide Pulse Therapy in Pemphigus: A Review of 72 Cases.
- Authors
Zivanovic, Dubravka; Medenica, Ljiljana; Tanasilovic, Srdjan; Vesic, Sonja; Skiljevic, Dusan; Tomovic, Maja; Nikolic, Milos M.
- Abstract
Background: Autoimmune pemphigus is a group of severe blistering diseases. Although corticosteroids have dramatically altered the prognosis of pemphigus, morbidity and mortality resulting from the adverse effects of systemic corticosteroids remain high. Dexamethasone-cyclophosphamide pulse (DCP) therapy was introduced to diminish the adverse effects of prolonged conventional daily dose regimens. Objective: To report our experience with the use of the DCP regimen in patients with autoimmune pemphigus. Methods: In the period 1998-2002, 72 patients with various forms of autoimmune pemphigus treated with DCP therapy were included, of whom 36 patients were previously treated with conventional corticosteroid therapy, and 36 were newly diagnosed patients. Results: Of the 72 patients, 43 completed treatment, while 13 patients did not respond adequately to the treatment and continued with the conventional daily regimen, nine patients were lost to follow-up, and seven patients died. Two of these deaths were probably a consequence of DCP therapy. Conclusion:DCPregimen is a beneficial treatment for patients with pemphigus, sparing the adverse effects of conventional regimens.
- Subjects
ADRENOCORTICAL hormones; DEXAMETHASONE; NITROGEN mustards; CYCLOPHOSPHAMIDE; PEMPHIGUS; DRUG dosage
- Publication
American Journal of Clinical Dermatology, 2010, Vol 11, Issue 2, p123
- ISSN
1175-0561
- Publication type
Article
- DOI
10.2165/11311150-000000000-00000