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- Title
EVALUATION OF MAST CELL STABILIZATION ACTIVITY OF MOMORDICA CHARANTIA IN RATS.
- Authors
Deshpande, S. D.; Salokhe, S. S.; Kolhe, S. U.; Tembhurne, S. V.
- Abstract
Mast cells have a major role in our immune system and they are also important targets in many inflammatory diseases. On degranulation, mast cells releases histamine and thereby produces inflammatory reaction and this makes it an important target in disease like asthma. The purpose of present investigation was to evaluate the potential of Momordica charantia (MC) on mast cell stabilization, as a parameter in management of asthma. In experimental animal the mast cell degranulation was induced by clonidine and the test extract was administered at doses of 100 and 200mg/kg (p.o.) and the standard used was ketotifen fumarate (1 mg/kg p.o). The result of study demonstrated that, extract of Momordica charantia significantly decreases the degranulation of mast cells indicating the protective effect. From this study it concludes that extract of Momordica charantia possess mast cell stabilizing effect.
- Subjects
MAST cells; MOMORDICA charantia; LABORATORY rats
- Publication
Journal of Advanced Scientific Research, 2020, Vol 11, p339
- ISSN
0976-9595
- Publication type
Article