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- Title
The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.
- Authors
Mlecnik, Bernhard; Bindea, Gabriela; Kirilovsky, Amos; Angell, Helen K.; Obenauf, Anna C.; Tosolini, Marie; Church, Sarah E.; Maby, Pauline; Vasaturo, Angela; Angelova, Mihaela; Fredriksen, Tessa; Mauger, Stéphanie; Waldner, Maximilian; Berger, Anne; Speicher, Michael R.; Pagès, Franck; Valge-Archer, Viia; Galon, Jérôme
- Abstract
The article presents a study which examines the Immunoscore and tumor microenvironment in cohorts of colorectal cancer patients. The study discovered two hallmarks of metastatic procedure, such ass lessened immune cytotoxicity and lessened presence of lymphatic vessels. The study showed the increased marginal lymphatic vessels and protective effect of the Immunoscore over the generation of distant metastases.
- Subjects
TUMOR microenvironment; COLON cancer patients; GENETICS of colon cancer; CELL-mediated cytotoxicity; METASTASIS
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 327, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aad6352