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- Title
Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells.
- Authors
Krajnović, Tamara; Pantelić, Nebojša Đ.; Wolf, Katharina; Eichhorn, Thomas; Maksimović-Ivanić, Danijela; Mijatović, Sanja; Wessjohann, Ludger A.; Kaluđerović, Goran N.
- Abstract
Xanthohumol (XN) and isoxanthohumol (IXN), prenylated flavonoids from Humulus lupulus, have been shown to possess antitumor/cancerprotective, antioxidant, antiinflammatory, and antiangiogenic properties. In this study, mesoporous silica (SBA-15) was loaded with different amounts of xanthohumol and isoxanthohumol and characterized by standard analytical methods. The anticancer potential of XN and IXN loaded into SBA-15 has been evaluated against malignant mouse melanoma B16F10 cells. When these cells were treated with SBA-15 containing xanthohumol, an increase of the activity correlated with a higher immobilization rate of XN was observed. Considering the amount of XN loaded into SBA-15 (calculated from TGA), an improved antitumor potential of XN was observed (IC50 = 10.8 ± 0.4 and 11.8 ± 0.5 µM for SBA-15|XN2 and SBA-15|XN3, respectively; vs. IC50 = 18.5 ± 1.5 µM for free XN). The main mechanism against tumor cells of immobilized XN includes inhibition of proliferation and autophagic cell death. The MC50 values for SBA-15 loaded with isoxanthohumol were over 300 µg/mL in all cases investigated.
- Subjects
MESOPOROUS silica; HOPS; IMMOBILIZED cells; MELANOMA; CELL proliferation
- Publication
Materials (1996-1944), 2022, Vol 15, Issue 14, pN.PAG
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma15145028