We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Green Synthesis of Silver Nanoparticles Using Populi gemmae Extract: Preparation, Physicochemical Characterization, Antimicrobial Potential and In Vitro Antiproliferative Assessment.
- Authors
Kis, Brigitta; Moacă, Elena-Alina; Tudoran, Lucian Barbu; Muntean, Delia; Magyari-Pavel, Ioana Zinuca; Minda, Daliana Ionela; Lombrea, Adelina; Diaconeasa, Zorita; Dehelean, Cristina Adriana; Dinu, Ștefania; Danciu, Corina
- Abstract
Green route is an economic, facile and eco-friendly method, employed for the synthesis of various types of nanoparticles, having it as a starting point biological entity, especially as a plant extract. The present study aims to obtain silver nanoparticles (AgNPs) starting from an ethanolic extract of Populi gemmae (Pg), by adjusting the reaction parameters. The morphological and structural characterization exhibited that both the reaction temperature and the concentration of metal salt, contributes to the obtaining of Pg-AgNPs with adjustable size and shape. The newly synthesized nanoparticles exhibited a good antibacterial activity on Gram-positive bacteria as well as antifungal activity. The in vitro antiproliferative activity of Pg-AgNPs was assessed on two different cancer cell lines (breast cancer cells—MCF7 and lung carcinoma epithelial cells—A549). Results have shown that the green-synthetized Pg-AgNPs_S2 (obtained at 60 °C, using AgNO3 of 5 M) induced a substantial decrease in tumor cell viability in a dose-dependent manner with an IC50 ranging from 5.03 to 5.07 µg/mL on A549 cell line and 3.24 to 4.93 µg/mL on MCF7 cell line.
- Subjects
SILVER nanoparticles; CELL lines; PLANT extracts; CANCER cells; GRAM-positive bacteria; EPITHELIAL cells
- Publication
Materials (1996-1944), 2022, Vol 15, Issue 14, pN.PAG
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma15145006