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- Title
Effect of Perillyl Alcohol (POH) A Monoterpene on Lipid Peroxidation and Antioxidant Status in High Fat Diet-Low Dose STZ Induced Type 2 Diabetes in Experimental Rats.
- Authors
Hassan, Towseef; C., Elanchezhiyan; Naseer, Insha; Marimuthu, S.
- Abstract
Aim: The plan of this study was to assess the protective activity of Perillyl alcohol (POH) on the levels of lipid peroxidation (LPO) by-products and antioxidant defense systems in the plasma and other tissues of normal and High Fat Diet-Low Dose Streptozotocin (STZ) induced type 2 diabetes in wistar rats. Materials and Methods: The experimental diabetes was induced in animals by High Fat Diet-Low Dose STZ (35 mg/kg i.p.) injection, and treatment with Perillyl alcohol at the dose of (50mg/kg b.w and 100mg/kg b.w) was continued for 30 days. At the end of treatment period, oxidative stress parameters like lipid peroxidation by-products; enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants including reduced glutathione, Vitamin C and Vitamin E were measured in the plasma and tissues of experimental rats. Results: In untreated diabetic rats an increase was seen in the levels of lipid peroxidation by-products and significant decrease was seen in antioxidant enzymes. Oral administration of Perillyl alcohol a monocyclic monoterpene to diabetic rats for 30 days caused a significant reduction in the levels of lipid peroxidation by-products and an increase in the activities of antioxidant enzymes, when the same were compared with the untreated diabetic group. Conclusion: The result of this study indicates that Perillyl alcohol has anti lipid peroxidation and antioxidant status potential in experimental diabetes.
- Subjects
PEROXIDATION; TYPE 2 diabetes; OXIDANT status; MONOTERPENES; STREPTOZOTOCIN; LIPID peroxidation (Biology); LIPIDS; FAT; VITAMIN E
- Publication
Pharmacognosy Journal, 2019, Vol 11, Issue 6, p1434
- ISSN
0975-3575
- Publication type
Article
- DOI
10.5530/pj.2019.11.222