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- Title
Effects of beta-sitosterol on inflammatory cytokines in high-fat diet-fed type-2 diabetic rats.
- Authors
Bharanishankar, S.; Vishnupriya, V.; Ponnulakshmi, R.; Gayathri, R.; Madhan, K.; Shyamaladevi, B.; Selvaraj, J.
- Abstract
Background: β-sitosterol is a naturally occurring plant sterol, ubiquitously found in many plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of β-sitosterol on inflammatory cytokines in high-fat diet (HFD)-fed type-2 diabetic rats is not known. Objectives: The study aimed to identify the effects of beta-sitosterol on inflammatory cytokines in HFD-fed type-2 diabetic rats. Methodology: β-sitosterol was administered orally to type-2 diabetic rats (20 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental animals was dissected out and the concentration of tumor necrosis factor (TNF)-α and interleukin (IL)-1 in serum sample of diabetes rats was determined by the use of a commercial enzyme-linked immunosorbent assay kit. Results: In type-2 diabetic animals, the TNF-α and IL-1c were found to be elevated in HFD-induced type-2 diabetic rats when compared with control. The β-sitosterol treatment significantly reduced the levels of TNF-α and IL-1 in type-2 diabetic rats. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol on inflammatory cytokines in HFD-fed type-2 diabetic rats.
- Subjects
STREPTOZOTOCIN; TUMOR necrosis factors; ENZYME-linked immunosorbent assay; RATS; CYTOKINES; HIGH-fat diet
- Publication
Drug Invention Today, 2019, Vol 12, Issue 5, p906
- ISSN
0975-7619
- Publication type
Article