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- Title
Proton pump inhibitor-induced hypomagnesemia - A review.
- Authors
Sanvas, U.; Praveen, D.; Chowdary, P. Ranadheer; Aanandhi, M. Vijey
- Abstract
Proton pump inhibitors (PPI) are the most commonly prescribed drugs for prevention and treatment of acid-related diseases. Hypomagnesemia has been recommended as one of the rare effects of the long-term use of PPIs. Hypomagnesemia occurs as a result of impaired magnesium absorption in the intestine. Prolonged hypomagnesemia can result in various systemic defects such as cardiac arrhythmias, tetany, seizures, and electrolytic imbalances such as hypocalcemia and hypokalemia. Magnesium supplement administration provides temporary relief and withdrawal or intermittent use of PPI on long-term therapy (=1 year) can reduce hypomagnesemia. Monitoring the serum Mg2+ routinely on long-term therapy helps to prevent the occurrence of hypomagnesemia to a great extent.
- Subjects
HYPOMAGNESEMIA; PROTON pump inhibitors; DRUG prescribing; DRUG dosage; PH effect; CLINICAL trials; THERAPEUTICS
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p219
- ISSN
0975-7619
- Publication type
Article