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- Title
In-vivo Study of Ameliorative Effect of Nardostachys jatamansi Against Electron Beam Induced Cytogenetic Damage.
- Authors
Naveen, P.; Kumari, N. Suchetha; Srinivasa, G.; Ramakrishna, M. K.; Ramesh, S. R.; Ganesh Sanjeev
- Abstract
The present study investigates the protective effect of Nardostachys jatamansi root extract on electron beam induced cytogenetic damage in-vivo in Wistar rats. N. jatamansi was given to male rats which were divided into five groups viz, control, drug control, irradiation control, pre-irradiation treatment and post irradiation treatment groups at a dose of 100 mg/kg body weight for 15 consecutive days with 3 Gy of electron beam. The DNA fragmentation, bone marrow micronucleus assay, chromosomal aberration and sperm morphology were performed according to standard procedures. The results showed that irradiation caused marked increase in the DNA fragmentation in liver cell, frequency of micronuclei polychromatic erythrocytes (mnPCE), chromosomal aberration in the bone marrow cell and sperm morphological abnormality. The pre and post-irradiation treatment with N. jatamansi has significantly countered radiation induced DNA fragmentation, micronuclei, chromosomal aberration and sperm morphology in the irradiated rats. The present study concludes that N. jatamansi has significant potential to protect cellular system from radiation induced damage and hence plays an important role in its radio protective action without any toxicity.
- Subjects
SPIKENARD; ELECTRON beams; DNA analysis; LABORATORY rats; BONE marrow cells; RADIATION protection
- Publication
Drug Invention Today, 2012, Vol 4, Issue 12, p659
- ISSN
0975-7619
- Publication type
Article