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- Title
The expression of adhesion molecules in muscle biopsies: the LFA-1/VLA-4 ratio in polymyositis.
- Authors
Lindvall, B.; Dahlbom, K.; Henriksson, K. G.; Srinivas, U.; Ernerudh, J.
- Abstract
Objectives – The expression of three pairs of adhesion receptors and ligands was examined in 22 consecutive muscle biopsies showing morphological signs of inflammation. Material and methods – The following groups were studied: patients with polymyositis (PM) (n =7), patients with myositis that did not fulfil criteria for PM, i.e. suspected PM (n =5), patients with other diseases, with no clinical signs of inflammatory myopathy (n =6), and a small group of non-PM inflammatory myopathies (n =4). The endothelial expression of ICAM-1, VCAM-1 and E-selectin was evaluated, as was the cellular expression of LFA-1, VLA-4 and SLex . In addition, the expression of MHC class I and II was studied. Results – The ratio between the number of cells expressing LFA-1 and VLA-4 showed significant differences between the groups, with the lowest values in PM. Conclusion – The LFA-1/VLA-4 ratio should be suitable for diagnostic purposes. Our findings also indicate that the VLA-4/VCAM-1 system is important for chronic T cell inflammation in muscle, in line with findings in other “hidden” organs like joints and the central nervous system.
- Subjects
CELL adhesion; DIAGNOSIS of muscle diseases; MAJOR histocompatibility complex
- Publication
Acta Neurologica Scandinavica, 2003, Vol 107, Issue 2, p134
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1034/j.1600-0404.2003.02062.x