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- Title
THE ANTI-INFLAMMATORY EFFECTS OF CURCUMIN NANOPARTICLES IN EXPERIMENTAL INDUCED MYOCARDIAL INFARCTION.
- Authors
Boarescu, Paul-Mihai; Boarescu, Ioana; Bulboacă, Adriana Elena; Bocșan, Ioana Corina; Pop, Raluca Maria; Gheban, Dan; Bolundut, Dinu; Bolboacă, Sorana D.
- Abstract
Objective: This study aimed to evaluate the anti-inflammatory effects of pre-treatment with curcumin nano-particles (CN) compared to conventional curcumin (CC) in isoproterenol(ISO)-induced myocardial infarction (MI). Methods: Seven groups containing eight adult female Wistar Bratislava rats/group assigned randomly were investigated. The first two groups were pre-treated with saline. Groups 3-5 were pre-treated with CC in doses of 100, 150, and 200 mg/kg bw and groups 6-8 were treated with CN in the same doses as CC, for 15 days. MI was induced in the 13th day with ISO in a dose of 100 mg/kg bw, which was subcutaneously injected at 24 h intervals for two days. The serum levels of six inflammatory cytokines, namely tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1α, IL-1β and IL-6, Monocyte Chemoattractant Protein-1 (MCP1), and Regulated upon Activation, Normal T cell Expressed, and Secreted (RANTES) were evaluated. Results: The serum levels of all studied cytokines were increased, up to 5.6 times, after the induction of MI. All CC and CN doses prevented elevation of TNF-α, IL-1α, IL-1β, and RANTES, with better results observed for CN as compared to CC (p≤0.0409). All doses of CN had a similar effect regarding the prevention of IL-6 elevation (p>0.05) with a significantly better effect than CC (p≤0.0409). MCP-1 levels were reduced by CN in the highest doses but were not influenced by CC (p>0.05). Conclusion: Curcumin nanoparticles possess increased antiinflamatory effect due to their ability to reduce serum levels of pro-inflammatory cytokines, in ISO-induced myocardial infarction.
- Subjects
INTERNATIONAL Organization for Standardization; MYOCARDIAL infarction; CURCUMIN; T cells; NANOPARTICLES
- Publication
Acta Medica Marisiensis, 2019, Vol 65, p7
- ISSN
2068-3324
- Publication type
Article