We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
婴儿痉挛症首次促肾上腺皮质激素治疗相关因素与 痉挛控制时间的Cox 比例风险回归模型分析
- Authors
万林; 杨光; 邹丽萍; 王静; 石秀玉; 任蔚华; 卢倩
- Abstract
Objective To investigate the factors in first-time adrenocorticotropic hormone (ACTH) therapy and their influence on spasm control time in infants with infantile spasms. Methods A total of 72 infants with infantile spasms who were admitted from January 2008 to October 2013 were enrolled. Their clinical data were collected, and the exposure factors for infantile spasms were selected. A Cox proportional-hazards regression model analysis was performed for these factors to analyze their influence on spasm control time. Results Clarification of the etiology (known or unexplained etiology), frequency of spasms before treatment, and presence or absence of combination therapy (ACTH used alone or in combination with magnesium sulfate) had a significant influence on spasm control time in infants with infantile spasms. The infants with a known etiology had a significantly shorter spasm control time than those with unexplained etiology, and the infants with a low frequency of spasms before treatment and receiving ACTH combined with magnesium sulfate early had a significantly longer spasm control time than their counterparts (P<0.05). Conclusions For infants with infantile spasms at initial diagnosis, etiology should be clarified, which may helpful for evaluating prognosis. A combination of ACTH and magnesium sulfate should be given as soon as possible, which may improve their prognosis.
- Subjects
INFANTILE spasms; MAGNESIUM sulfate; ADRENOCORTICOTROPIC hormone; SPASMS; REGRESSION analysis
- Publication
Chinese Journal of Contemporary Pediatrics, 2019, Vol 21, Issue 9, p845
- ISSN
1008-8830
- Publication type
Article
- DOI
10.7499/j.issn.1008-8830.2019.09.001