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- Title
Causes of Colectomy in Patients with Ulcerative Colitis: Findings from an Iranian National Registry.
- Authors
Sanat, Zahra Momayez; Vahedi, Homayoon; Malekzadeh, Reza; Kasaeian, Amir; Ganjaroudi, Negar Mohammadi; Sima, Alireza; Ghanaei, Fariborz Mansour; Ghadir, Mohammadreza; Fakheri, Hafez Tirgar; Moghaddam, Siavosh Nasseri; Alatab, Sudabeh; Sadeghi, Anahita; Anushiravani, Amir; Maleki, Iradj; Yazdanbod, Abbas; Vossoughinia, Hassan; Seyyedmajidi, Mohammadreza; Naghshbandi, Sayed Jalaleddin; Baniasadi, Nadieh; Parhizkar, Baran
- Abstract
Background: Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) marked by rectal and colon inflammation, leading to relapsing symptoms. Its prevalence is increasing, particularly in developed nations, impacting patients' health. While its exact cause remains unclear, genetic and environmental factors are implicated, elevating the risk of colorectal cancer (CRC). Colectomy, though declining, is still performed in select UC cases, necessitating further study. Methods: We analyzed data from the Iranian Registry of Crohn's and Colitis (IRCC) to examine UC patients undergoing colectomy. We collected demographic and clinical data from 91 patients, focusing on dysplasia. Statistical analyses assessed dysplasia risk factors. Results: Patients with dysplasia were older at diagnosis and surgery compared to those without dysplasia. Age emerged as a significant risk factor for dysplasia in UC patients undergoing colectomy. No significant associations were found between dysplasia and other factors. Conclusion: Age plays a crucial role in dysplasia risk among UC patients undergoing colectomy. Older age at diagnosis and surgery may indicate a higher risk of dysplasia and CRC. Clinicians should consider age when managing UC patients and implementing screening protocols. Further research with larger samples is needed to confirm these findings.
- Subjects
IRAN; RISK assessment; CROSS-sectional method; SURGERY; PATIENTS; RESEARCH funding; PRECANCEROUS conditions; ULCERATIVE colitis; AGE distribution; COLORECTAL cancer; RETROSPECTIVE studies; REPORTING of diseases; MEDICAL records; ACQUISITION of data; COMPARATIVE studies; COLECTOMY; DISEASE risk factors
- Publication
Archives of Iranian Medicine (AIM), 2024, Vol 27, Issue 7, p350
- ISSN
1029-2977
- Publication type
Article
- DOI
10.34172/aim.28887